MOTS-C

MOTS-c

Premium Bioactive Peptide for Mitochondrial Research, Cellular Metabolism and Energy Physiology

Research Category: Mitochondrial Biology • Cellular Metabolism • Energy Physiology

Why Choose MOTS-c from Nedermann Lab?

At Nedermann Lab, we believe that research materials should offer more than technical specifications. Every batch of MOTS-c is accompanied by comprehensive documentation and undergoes documented quality control procedures to ensure analytical consistency and reliability.

Our goal is to provide research materials characterized by batch-to-batch consistency, full traceability, and technical documentation, enabling researchers, laboratories, and academic institutions to work with materials that meet the highest standards required for scientific research.

Nedermann Lab Quality Standards

At Nedermann Lab, quality is a documented process, not simply a specification.

Every batch of MOTS-c is evaluated to ensure analytical consistency, product integrity, and complete traceability throughout the manufacturing process.

To achieve this, each production batch undergoes documented quality control procedures using validated analytical methods to verify product identity and confirm compliance with established technical specifications. This approach provides researchers with highly consistent and reproducible research materials suitable for demanding laboratory applications.

Product Highlights

✔ ≥99% analytical purity, verified by High Performance Liquid Chromatography (HPLC)

✔ Certificate of Analysis (COA) available for every production batch

✔ Lyophilized powder for enhanced laboratory stability and handling

✔ Rigorous quality control and complete batch traceability

✔ Professional packaging in laboratory-grade borosilicate glass vials

✔ Fast shipping from our European warehouse

✔ Intended exclusively for Research Use Only (RUO)

What Is MOTS-c?

Within the field of mitochondrial peptide research, only a limited number of naturally occurring peptides have attracted significant scientific interest in recent years. MOTS-c is one of these molecules, recognized in the scientific literature as a mitochondrial-derived peptide (MDP) widely investigated in studies involving cellular metabolism, energy physiology, mitochondrial biology, and metabolic regulation.

Unlike many research peptides, interest in MOTS-c is not limited to a single scientific discipline. Scientific literature describes its use in studies involving mitochondrial signaling, cellular energy metabolism, metabolic homeostasis, stress adaptation, endocrine communication, and the biological mechanisms associated with maintaining normal cellular function.

The MOTS-c supplied by Nedermann Lab is manufactured and verified according to documented quality control procedures and is analytically characterized to confirm its identity and purity. This approach ensures a high level of batch-to-batch consistency while providing researchers with reliable material for laboratory studies and experimental applications.

From a structural perspective, MOTS-c is a naturally occurring mitochondrial-derived peptide encoded within mitochondrial DNA. In the scientific literature, this molecule is widely used as an experimental model to investigate the biological mechanisms involved in mitochondrial communication, cellular metabolism, energy regulation, and metabolic physiology.

Key Areas of Scientific Research

Cellular Energy Production

One of the primary areas of research involving MOTS-c focuses on how cells produce and use energy. Scientific studies investigate the biological pathways responsible for maintaining normal cellular energy production and metabolic function under laboratory conditions.

Fat Metabolism Research

Current research investigates the biological mechanisms involved in fat metabolism and how cells utilize stored energy. These studies help researchers better understand the molecular pathways associated with metabolic balance.

Blood Sugar Regulation Research

Scientific publications explore the biological pathways involved in glucose metabolism and metabolic homeostasis. Researchers investigate how mitochondrial signaling contributes to maintaining normal metabolic function in experimental models.

Mitochondrial Health

Mitochondria are often referred to as the "powerhouses" of the cell because they produce the energy required for normal cellular function. MOTS-c is widely investigated in studies exploring mitochondrial communication and energy regulation.

Healthy Aging Research

Scientific investigations explore the biological mechanisms associated with healthy aging and long-term cellular function. Current research focuses on how mitochondrial biology may influence these complex biological processes.

Exercise and Physical Performance Research

Researchers also investigate the biological pathways associated with energy utilization, physical activity, and metabolic adaptation during exercise under laboratory conditions.

Scientific Literature and Current Research Directions

Since its discovery, MOTS-c has been investigated by universities, academic institutions, and specialized research laboratories worldwide. Today, it is recognized as one of the most extensively studied mitochondrial-derived peptides in the scientific literature dedicated to mitochondrial biology, cellular metabolism, and metabolic physiology.

Ongoing research continues to expand our understanding of its interactions with biological pathways involved in mitochondrial signaling, cellular energy metabolism, metabolic homeostasis, endocrine communication, stress adaptation, and healthy aging research. Advances in molecular biology, mitochondrial science, and metabolic research have further increased scientific interest in this molecule, providing researchers with new opportunities for experimental investigation and fundamental biological research.

Key Scientific Publications

Professor Pinchas Cohen – Pioneer of Mitochondrial-Derived Peptide Research

The scientific work of Professor Pinchas Cohen has played a fundamental role in advancing the understanding of mitochondrial-derived peptides, including MOTS-c. His research has significantly contributed to expanding knowledge of mitochondrial communication, metabolic regulation, and the biological mechanisms involved in maintaining normal cellular function.

His publications remain among the most frequently cited scientific references related to MOTS-c and continue to support ongoing research in mitochondrial biology, metabolism, and healthy aging.

Featured Scientific Publication

Lee C. et al.

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Published in Cell Metabolism, this peer-reviewed publication investigates the biological characteristics of MOTS-c and its interactions with pathways associated with mitochondrial signaling, cellular metabolism, energy physiology, and metabolic homeostasis.

Storage & Handling

MOTS-c is supplied as a lyophilized peptide powder in laboratory-grade borosilicate glass vials designed for research applications.

To preserve product integrity throughout storage, researchers should follow the storage recommendations provided on the product label and handle the material according to established laboratory practices.

Before Reconstitution

• Store the vial in its original packaging.

• Keep in a cool, dry place away from direct sunlight and moisture.

• Avoid repeated freeze-thaw cycles and exposure to excessive temperatures.

• Handle under appropriate laboratory conditions.

After Reconstitution

• Store the reconstituted solution at 2–8°C (36–46°F).

• Recommended storage period: up to 28 days.

• Do not refreeze the reconstituted solution.

The stability of the prepared solution may vary depending on the solvent used, handling procedures, and laboratory storage conditions. Reconstitution should always be performed according to validated laboratory protocols and Good Laboratory Practice (GLP) guidelines.

Product Appearance

MOTS-c is supplied as a white to off-white lyophilized powder.

After reconstitution, the solution should appear clear and colorless under appropriate laboratory conditions. Minor variations in appearance may occur depending on the solvent used and the reconstitution procedure and should not be considered a manufacturing defect.

Frequently Asked Questions (FAQ)

What is MOTS-c?

MOTS-c is a naturally occurring mitochondrial-derived peptide (MDP) developed for scientific research. In the scientific literature, it is widely used as a research material in studies involving mitochondrial biology, cellular metabolism, energy physiology, metabolic homeostasis, and endocrine communication.

Why has MOTS-c attracted significant scientific interest?

Scientific interest in MOTS-c is supported by a rapidly growing body of published research investigating its biological mechanisms and its role in mitochondrial communication. It is recognized as one of the most extensively investigated mitochondrial-derived peptides in studies related to cellular metabolism, energy regulation, healthy aging, and metabolic physiology.

What does "Research Use Only" mean?

Products labeled Research Use Only (RUO) are intended exclusively for laboratory research and analytical applications.

They are not approved for human or veterinary use and are not intended for the diagnosis, treatment, cure, or prevention of any disease.

How is product quality verified?

Every production batch undergoes documented quality control procedures, including analytical verification of product identity and purity. Batch-specific documentation is available through the accompanying Certificate of Analysis (COA).

Why is purity verified using HPLC?

High Performance Liquid Chromatography (HPLC) is one of the most widely accepted analytical techniques for verifying peptide identity and purity.

HPLC analysis helps confirm the analytical purity of each batch while ensuring manufacturing consistency and quality control throughout production.

Why is the Certificate of Analysis (COA) important?

The Certificate of Analysis (COA) is an official quality document accompanying each production batch.

It provides essential analytical information, including product identification, test results, and confirmation that the batch meets predefined technical specifications. The COA also supports traceability, quality assurance, and research documentation.

Disclaimer

All products supplied by Nedermann Lab are intended exclusively for Research Use Only (RUO)!

These products are not medicines, dietary supplements, medical devices, cosmetics, or products intended for human or veterinary use!

The information presented on this website is provided for informational and scientific reference purposes only and is based on publicly available scientific literature. References to published studies and scientific publications are intended to describe areas of ongoing research and should not be interpreted as claims regarding the safety, efficacy, or clinical application of any product.

Nedermann Lab does not promote, recommend, or authorize the use of its products for any purpose other than legitimate laboratory research.

By purchasing products from Nedermann Lab, customers acknowledge that they are qualified to handle research materials, will comply with all applicable laws and regulations, and will use these products solely for their intended research purposes.